Article
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jun 1998
Winter D B, Phung Q H, Umar A, Baker S M, Tarone R E, Tanaka K, Liskay R M, Kunkel T A, Bohr V A, Gearhart P J
Abstract excerpt
Mutations are introduced into rearranged Ig variable genes at a frequency of 10(-2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair. Therefore, hypermutation was studied in mice deficient for either the DNA nucleotide excision repair gene Xpa or...
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