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Article

PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice.

Molecular immunology - 1 Feb 1999

Kong Q, Maizels N

Abstract excerpt

The Pms2 gene is involved in DNA mismatch repair in mammalian cells, and has recently been shown to affect hypermutation of mammalian immunoglobulin genes. We have studied hypermutation of a lambda1 transgene in chronically stimulated Peyer's patch B cells of both young and old mice deficient in function of Pms2. In young (3-4 months) mice, somatic hypermutation is fourfold lower in PMS2-deficient mice than in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10378680
DOI: 10.1016/s0161-5890(99)00027-9

Genes

PMS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice.PMID 10378680Read ↗

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