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Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

12 May 2003

Abstract excerpt

Mismatch repair proteins participate in antibody class switch recombination, although their roles are unknown. Previous nucleotide sequence analyses of switch recombination junctions indicated that the roles of Msh2 and the MutL homologues, Mlh1 and Pms2, differ. We now asked if Msh2 and Mlh1 function in the same pathway during switch recombination. Splenic B cells from mice deficient in both these proteins were...

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PMID: 12743174
DOI: 10.1084/jem.20022190

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Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2PMID 12743174Read ↗

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern.Semantic proximity Read ↗

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