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Article

A role for Mlh3 in somatic hypermutation.

DNA repair - 10 Jun 2006

Li Ziqiang, Peled Jonathan U, Zhao Chunfang, Svetlanov Anton, Ronai Diana, Cohen Paula E, Scharff Matthew D

Abstract excerpt

Somatic hypermutation (SHM) and class switch recombination (CSR) allow B cells to make high affinity antibodies of various isotypes. Both processes are initiated by activation-induced cytidine deaminase (AID) to generate dG:dU mismatches in the immunoglobulin genes that are resolved differently in SHM and CSR to introduce point mutations and recombination, respectively. The MutL homolog MLH3 has been implicated...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16564751
DOI: 10.1016/j.dnarep.2006.02.003

Genes

MLH1
MLH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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A role for Mlh3 in somatic hypermutation.PMID 16564751Read ↗

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A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch RecombinationSemantic proximity Read ↗

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