Article
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.
Carcinogenesis - 1 Feb 2000
Kawate H, Itoh R, Sakumi K, Nakabeppu Y, Tsuzuki T, Ide F, Ishikawa T, Noda T, Nawata H, Sekiguchi M
Abstract excerpt
Mice with mutations in both alleles of the Mgmt and the Mlh1 gene, the former encoding a DNA repair methyltransferase and the latter a protein functioning at an early step of mismatch repair, are as resistant to the killing action of alkylating agents as are wild-type mice. These mice yielded a large number of tumors when exposed to alkylating carcinogens, but this characteristic was subdued since they also...
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