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Article

Inactivation of DNA mismatch repair by increased expression of yeast MLH1.

Molecular and cellular biology - 1 Feb 2001

Shcherbakova P V, Hall M C, Lewis M S, Bennett S E, Martin K J, Bushel P R, Afshari C A, Kunkel T A

Abstract excerpt

Inactivation of DNA mismatch repair by mutation or by transcriptional silencing of the MLH1 gene results in genome instability and cancer predisposition. We recently found (P. V. Shcherbakova and T. A. Kunkel, Mol. Cell. Biol. 19:3177-3183, 1999) that an elevated spontaneous mutation rate can also result from increased expression of yeast MLH1. Here we investigate the mechanism of this mutator effect....

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Source

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Identifiers

PMID: 11154280
DOI: 10.1128/MCB.21.3.940-951.2001
PMCID: PMC86684

Genes

MLH1
PMS1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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