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Article

Relaxed replication of mtDNA: A model with implications for the expression of disease.

American journal of human genetics - 1 Apr 1999

Chinnery P F, Samuels D C

Abstract excerpt

Heteroplasmic mtDNA defects are an important cause of human disease with clinical features that primarily involve nondividing (postmitotic) tissues. Within single cells the percentage level of mutated mtDNA must exceed a critical threshold level before the genetic defect is expressed. Although the level of mutated mtDNA may alter over time, the mechanism behind the change is not understood. It currently is not...

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Identifiers

PMID: 10090901
DOI: 10.1086/302311
PMCID: PMC1377840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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