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Article

Functional complementation of mitochondrial DNAs: mobilizing mitochondrial genetics against dysfunction.

Biochimica et biophysica acta - 1 Mar 2010

Schon Eric A, Gilkerson Robert W

Abstract excerpt

Human mitochondrial DNA (mtDNA) is a 16.6-kb circular genome that is typically found in approximately 1000 copies per cell. Frequently, one or more forms of mtDNA (i.e. wildtype (WT) and one or more mutant variants) will co-exist within an individual cell, a situation termed heteroplasmy; however, it has been unclear how different mitochondria and mtDNA populations interact functionally in a heteroplasmic cell...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19616602
DOI: 10.1016/j.bbagen.2009.07.007

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