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Article

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

American journal of human genetics - 1 Mar 2001

Elson J L, Samuels D C, Turnbull D M, Chinnery P F

Abstract excerpt

Human tissues acquire somatic mitochondrial DNA (mtDNA) mutations with age. Very high levels of specific mtDNA mutations accumulate within individual cells, causing a defect of mitochondrial oxidative metabolism. This is a fundamental property of nondividing tissues, but it is not known how it comes about. To explore this problem, we developed a model of mtDNA replication within single human cells. Using this...

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Identifiers

PMID: 11179029
DOI: 10.1086/318801
PMCID: PMC1274494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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