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Article

Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA.

Genetical research - 1 Apr 2006

Loewe Laurence

Abstract excerpt

The observation of high mitochondrial mutation rates in human pedigrees has led to the question of how such an asexual genetic system can survive the accumulation of slightly deleterious mutations caused by Muller's ratchet. I define a null model to quantify in unprecedented detail the threat from extinction caused by Muller's ratchet. This model is general enough to explore the biological significance of...

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Identifiers

PMID: 16709275
DOI: 10.1017/S0016672306008123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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