Article
Mechanisms of human mitochondrial DNA maintenance: the determining role of primary sequence and length over function.
Molecular biology of the cell - 1 Oct 1999
Moraes C T, Kenyon L, Hao H
Abstract excerpt
Although the regulation of mitochondrial DNA (mtDNA) copy number is performed by nuclear-coded factors, very little is known about the mechanisms controlling this process. We attempted to introduce nonhuman ape mtDNA into human cells harboring either no mtDNA or mutated mtDNAs (partial deletion and tRNA gene point mutation). Unexpectedly, only cells containing no mtDNA could be repopulated with nonhuman ape...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.