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Article

The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells

1 Mar 1999

Abstract excerpt

HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N.,...

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Identifiers

PMID: 10085150
DOI: 10.1074/jbc.274.13.9022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa CellsPMID 10085150Read ↗

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.Semantic proximity Read ↗

Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron RegulationSemantic proximity Read ↗

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.Semantic proximity Read ↗

The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment.Semantic proximity Read ↗

Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis.Semantic proximity Read ↗

Molecular aspects of iron absorption and HFE expression.Semantic proximity Read ↗

The Hereditary Hemochromatosis Protein, HFE, Inhibits Iron Uptake via Down-regulation of Zip14 in HepG2 CellsSemantic proximity Read ↗

The structure and function of HFE.Semantic proximity Read ↗

Physiology of iron transport and the hemochromatosis gene.Semantic proximity Read ↗

The hemochromatosis protein HFE inhibits iron export from macrophages.Semantic proximity Read ↗

HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell SurfaceSemantic proximity Read ↗

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