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HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell Surface

1 Jun 2004

Abstract excerpt

Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis. HFE and Fe-Tf can bind simultaneously to TfR to form a ternary complex, but HFE binding to TfR lowers the apparent affinity of the Fe-Tf/TfR interaction. This apparent affinity...

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PMID: 15056661
DOI: 10.1074/jbc.m401467200

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HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell SurfacePMID 15056661Read ↗

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