Article
The hereditary hemochromatosis protein HFE and its chaperone beta2-microglobulin localise predominantly to the endosomal-recycling compartment.
Biochemical and biophysical research communications - 27 Jul 2007
Bhatt Lavinia, Horgan Conor P, Walsh Melanie, McCaffrey Mary W
Abstract excerpt
Hereditary Hemochromatosis is an iron overload disease most frequently associated with mutations in the HFE gene. While clinical studies of the disease have received extensive attention by various groups, the localisation, trafficking and function of the HFE protein, and its chaperone beta2-microglobulin (beta2M), require further investigation. In this study, we present data on the cellular localisation of HFE...
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