Article
The hemochromatosis protein HFE inhibits iron export from macrophages.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002
Drakesmith Hal, Sweetland Emma, Schimanski Lisa, Edwards Jon, Cowley Diana, Ashraf Mubeen, Bastin Judy, Townsend Alain R M
Abstract excerpt
Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macrophages and intestinal crypt cells, which behave as though they are relatively iron-deficient in HH....
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