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Article

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Zhang An-Sheng, Davies Paige S, Carlson Hanqian L, Enns Caroline A

Abstract excerpt

The mechanisms by which the hereditary hemochromatosis protein, HFE, decreases transferrin-mediated iron uptake were examined. Coimmunoprecipitation studies using solubilized cell extracts demonstrated that transferrin (Tf) competed with HFE for binding to the transferrin receptor (TfR) similar to previous in vitro studies using soluble truncated forms of HFE and the TfR. At concentrations of Tf approaching those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12874382
DOI: 10.1073/pnas.1233675100
PMCID: PMC170947

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.PMID 12874382Read ↗

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Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

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