Article
Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis.
Biological research - 1 Jan 2006
Enns Caroline A
Abstract excerpt
Hereditary hemochromatosis (HH) is the most common inherited disorder in people of Northern European descent. Over 83% of the cases of HH result from a single mutation of a Cys to Tyr in the HH protein. HFE. This mutation causes a recessive disease resulting in an accumulation of iron in selected tissues. Iron overload damages these organs leading to cirrhosis of the liver, diabetes, cardiomyopathy, and...
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