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Article

The structure and function of HFE.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jul 2000

Drakesmith H, Townsend A

Abstract excerpt

The iron overload disease hereditary haemochromatosis (HH) occurs in about 1 in 300 Caucasians; the protein mutated in this disorder is termed HFE.(1) HFE is homologous to major histocompatibility complex (MHC) class I proteins, but unlike MHC class I molecules, HFE does not present peptides to T cells.(2) The transferrin receptor (TfR) is a ligand for HFE, and the crystal structure of the HFE-TfR complex has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10878571
DOI: 10.1002/1521-1878(200007)22:7<595::AID-BIES1>3.0.CO;2-E

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis.Semantic proximity Read ↗

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