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Article

Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation

1 Aug 1998

Abstract excerpt

The mechanism by which a novel major histocompatibility complex class I protein, HFE, regulates iron uptake into the body is not known. HFE is the product of the gene that is mutated in >80% of hereditary hemochromatosis patients. It was recently found to coprecipitate with the transferrin receptor (Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J. A., Watson, N., Tsuchihashi, Z., Sigal, E.,...

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Identifiers

PMID: 9705350
DOI: 10.1074/jbc.273.34.22068

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Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron RegulationPMID 9705350Read ↗

The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa CellsSemantic proximity Read ↗

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation.Semantic proximity Read ↗

HFE and Transferrin Directly Compete for Transferrin Receptor in Solution and at the Cell SurfaceSemantic proximity Read ↗

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin.Semantic proximity Read ↗

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand bindingSemantic proximity Read ↗

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.Semantic proximity Read ↗

Molecular aspects of iron absorption and HFE expression.Semantic proximity Read ↗

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosisSemantic proximity Read ↗

The hemochromatosis protein HFE inhibits iron export from macrophages.Semantic proximity Read ↗

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.Semantic proximity Read ↗

The structure and function of HFE.Semantic proximity Read ↗

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