Article
Molecular aspects of iron absorption and HFE expression.
Gastroenterology - 1 Dec 2001
Parkkila S, Niemelä O, Britton R S, Fleming R E, Waheed A, Bacon B R, Sly W S
Abstract excerpt
Hereditary hemochromatosis, a disease of iron overload, occurs in about 1 in 200-400 Caucasians. The gene mutated in this disorder is termed HFE. The product of this gene, HFE protein, is homologous to major histocompatibility complex class I proteins, but HFE does not present peptides to T cells. Based on recent structural, biochemical, and cell biological studies, transferrin receptor (TfR) is a ligand for HFE....
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