Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis

doi:10.1073/pnas.042701499

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Article

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis

26 Feb 2002

Abstract excerpt

The protein defective in hereditary hemochromatosis, called HFE, is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). Its association with beta2M was previously shown to be necessary for its stability, normal intracellular processing, and cell surface expression in transfected COS cells. Here we use stably transfected Chinese hamster ovary cell lines expressing both HFE and...

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PMID: 11867720
DOI: 10.1073/pnas.042701499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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