Article
Mutations in the p53 and scid genes do not cooperate in lymphomagenesis in doubly heterozygous mice.
Biochemical and biophysical research communications - 5 Feb 1999
Kosugi S, Miyazawa T, Chou D, Saito Y, Shinbo T, Matsuki A, Okano H, Miyaji C, Watanabe H, Hatakeyama K, Niwa O, Kominami R
Abstract excerpt
Analysis of double mutant mice of the p53 and scid genes, which have a combination of cell cycle checkpoint/apoptosis and DNA repair defects, shows that the latter defect synergistically enhances lymphoma development with loss of the former function. These mice lack the ability to eliminate lymphocytes predisposed to neoplastic transformation resulting from faulty antigen receptor gene rearrangement. Here we...
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