Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis.

doi:10.1084/jem.176.2.399

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Article

Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis.

The Journal of experimental medicine - 1 Aug 1992

Lieberman M, Hansteen G A, Waller E K, Weissman I L, Sen-Majumdar A

Abstract excerpt

Strain C.B17 scid/scid (SCID) mice, which lack functional T and B lymphocytes, show heightened susceptibility to the induction of thymic lymphomas by x-irradiation. Susceptibility is highest in thymus-chimeric SCID-BL mice (thymectomized SCID mice bearing a C57BL thymus graft). All SCID-BL lympho...

Topics

Animals
Bone Marrow
Lymphoma
Mice
Mice, Inbred C57BL
Mice, SCID
Mutation
Phenotype
Radiation Tolerance
Severe Combined Immunodeficiency
Thymus Gland
X-Rays

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