Article
Reduced sensitivity to and ras mutation spectrum of N-ethyl-N-nitrosourea-induced thymic lymphomas in adult C.B-17 scid mice.
Mutation research - 4 Sept 2001
Nishimura M, Kakinuma S, Wakana S, Mukaigawara A, Mita K, Sado T, Ogiu T, Shimada Y
Abstract excerpt
Scid mice are defective in the ability to repair DNA double strand breaks and, as a consequence, their cells are radiosensitive. Further, they have been shown to be prone to develop thymic lymphomas (TLs) after small doses of ionizing radiation. Little is known, however, on the role of scid mutation in chemical carcinogenesis. To determine if scid mutation increased predisposition to chemical carcinogenesis, we...
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