Article
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.
Mutation research - 15 Jan 2009
Tsuji Hideo, Ishii-Ohba Hiroko, Noda Yuko, Kubo Eiko, Furuse Takeshi, Tatsumi Kouichi
Abstract excerpt
The pathways of thymic lymphomagenesis are classified as Rag-dependent or -independent according to their dependence on recombination-activating gene (Rag1/2) proteins. The role of the two-lymphoma pathways in oncogene rearrangements and the connection between lymphoma pathways and rearrangement mechanisms, however, remain obscure. We compared the incidence and latency of thymic lymphomas, and associated...
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