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Article

The SCID mouse mutant: definition, characterization, and potential uses.

Annual review of immunology - 1 Jan 1991

Bosma M J, Carroll A M

Abstract excerpt

Mice homozygous for the scid mutation (scid mice) are severely deficient in functional B and T lymphocytes. The mutation appears to impair the recombination of antigen receptor genes and thereby causes an arrest in the early development of B and T lineage-committed cells; other hematopoietic cell types appear to develop and function normally. The arrest in lymphocyte development is not absolute; some young adult...

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PMID: 1910681
DOI: 10.1146/annurev.iy.09.040191.001543

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