Article
The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links.
Mutation research - 1 Aug 1993
Tanaka T, Yamagami T, Oka Y, Nomura T, Sugiyama H
Abstract excerpt
The sensitivity of scid fibroblasts established from C.B17-scid/scid fetuses to the DNA-damaging agents bleomycin, neocarzinostatin, mechlorethamine, mitomycin C, methyl methanesulfonate, and ultraviolet light, all of which induce different types of DNA damage, was examined. Scid fibroblasts were 2.8-, 3.7-, and 3.0-fold more sensitive to bleomycin, neocarzinostatin, and mechlorethamine, respectively, than...
Topics
- Animals
- Bleomycin
- Cell Line
- Cell Survival
- DNA Damage
- DNA Repair
- Female
- Male
- Mechlorethamine
- Mice
- Mice, SCID
- Mutation