Article
Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Reichman-Fried M, Hardy R R, Bosma M J
Abstract excerpt
Mice homozygous for the mutation scid (scid mice) are severely immunodeficient and generally lack detectable numbers of pre-B, B, and T cells. This condition is believed to result from a defect in the mechanism responsible for rearrangement of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes. To test this hypothesis and evaluate whether scid affects only the process of gene...
Topics
- Animals
- B-Lymphocytes
- Bone Marrow
- Bone Marrow Cells
- Gene Rearrangement
- Genes, Immunoglobulin
- Genotype
- Immunoglobulin M
- Immunologic Deficiency Syndromes
- Mice
- Mice, Inbred Strains