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Article

PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila.

PLoS genetics - 5 Mar 2010

Johnson Matthew L, Nagengast Alexis A, Salz Helen K

Abstract excerpt

Alternative splicing controls the expression of many genes, including the Drosophila sex determination gene Sex-lethal (Sxl). Sxl expression is controlled via a negative regulatory mechanism where inclusion of the translation-terminating male exon is blocked in females. Previous studies have shown that the mechanism leading to exon skipping is autoregulatory and requires the SXL protein to antagonize exon...

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PMID: 20221253
DOI: 10.1371/journal.pgen.1000872
PMCID: PMC2832672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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