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Article

spenito is required for sex determination in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2015

Yan Dong, Perrimon Norbert

Abstract excerpt

Sex-lethal (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by controlling sex identity in both soma and germ line. In females Sxl maintains its own expression by controlling the alternative splicing of its own mRNA. Here, we identify a novel sex determination gene, spenito (nito) that encodes a SPEN family protein. Loss of nito activity results in stem cell tumors in the...

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Identifiers

PMID: 26324914
DOI: 10.1073/pnas.1515891112
PMCID: PMC4577178

Genes

SPEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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