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Article

The master switch gene sex-lethal promotes female development by negatively regulating the N-signaling pathway.

Developmental cell - 1 Feb 2007

Penn Jill K M, Schedl Paul

Abstract excerpt

Notch (N) signaling is used for cell-fate determination in many different developmental contexts. Here, we show that the master control gene for sex determination in Drosophila melanogaster, Sex-lethal (Sxl), negatively regulates the N-signaling pathway in females. In genetic assays, reducing Sxl activity suppresses the phenotypic effects of N mutations, while increasing Sxl activity enhances the effects. Sxl...

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Identifiers

PMID: 17276344
DOI: 10.1016/j.devcel.2007.01.009
PMCID: PMC4362774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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