Article
Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom.
Arthritis and rheumatism - 1 Mar 2002
MacKay Kirsten, Eyre Stephen, Myerscough Anne, Milicic Anita, Barton Anne, Laval Steven, Barrett Jenny, Lee Dorothea, White Sarah, John Sally, Brown Matthew A, Bell John, Silman Alan, Ollier William, Wordsworth Paul, Worthington Jane
Abstract excerpt
OBJECTIVE: To undertake a systematic whole-genome screen to identify regions exhibiting genetic linkage to rheumatoid arthritis (RA). METHODS: Two hundred fifty-two RA-affected sibling pairs from 182 UK families were genotyped using 365 highly informative microsatellite markers. Microsatellite genotyping was performed using fluorescent polymerase chain reaction primers and semiautomated DNA sequencing technology....
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