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Article

Inhibition of hTAFII32-binding implicated in the transcriptional repression by central regions of mutant p53 proteins.

The Journal of biological chemistry - 19 Mar 1999

Tung S F, Chuang J Y, Lin C T, Lai M Y, Wu C W, Lin Y S

Abstract excerpt

We previously identified a movable and regulable inactivation function within the central region (CRts247) of a temperature-sensitive p53 (p53(ts)) mutant, p53(N247I). Here we showed that central regions from several p53(ts) mutants behaved similarly, i.e. they repressed a neighboring activation domain only when existing in the mutant status. Using chimeric protein GAL4VP16-CRts247 as an example, we demonstrated...

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PMID: 10075665
DOI: 10.1074/jbc.274.12.7748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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