Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

doi:10.1016/0092-8674(90)90113-s

Back to search

Article

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

Cell - 24 Aug 1990

Michalovitz D, Halevy O, Oren M

Abstract excerpt

Mutant p53 can contribute to transformation, while wild-type (wt) p53 is not oncogenic and actually inhibits transformation. Furthermore, wt p53 may act as a suppressor gene in human carcinogenesis. We now describe the temperature-sensitive behavior of a particular mutant, p53val135. Like other p...

Topics

Animals
Cell Cycle
Cell Division
Cell Transformation, Neoplastic
Cloning, Molecular
Mice
Mutation
Oncogene Proteins
Oncogenes
Phosphoproteins
Rats
Temperature
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.