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Article

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

Cell - 24 Aug 1990

Michalovitz D, Halevy O, Oren M

Abstract excerpt

Mutant p53 can contribute to transformation, while wild-type (wt) p53 is not oncogenic and actually inhibits transformation. Furthermore, wt p53 may act as a suppressor gene in human carcinogenesis. We now describe the temperature-sensitive behavior of a particular mutant, p53val135. Like other p53 mutants, it can elicit transformation at 37.5 degrees C. However, at 32.5 degrees C it suppresses transformation,...

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Identifiers

PMID: 2143698
DOI: 10.1016/0092-8674(90)90113-s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.PMID 2143698Read ↗

The role of p53 in the normal control of cell proliferation.Semantic proximity Read ↗

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.Semantic proximity Read ↗

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.Semantic proximity Read ↗

Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis.Semantic proximity Read ↗

p53Val135 temperature sensitive mutant suppresses growth of human breast cancer cells.Semantic proximity Read ↗

Transcriptional activation by p53 correlates with suppression of growth but not transformation.Semantic proximity Read ↗

Temperature sensitivity of human wild-type and mutant p53 proteins expressed in vivo.Semantic proximity Read ↗

Transactivation by temperature-dependent p53 mutants in yeast and human cells.Semantic proximity Read ↗

Temperature-sensitive mutants of p53 homologs.Semantic proximity Read ↗

Different tumor-derived p53 mutants exhibit distinct biological activities.Semantic proximity Read ↗

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A temperature-sensitive mutant of human p53.Semantic proximity Read ↗

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