Temperature sensitivity of human wild-type and mutant p53 proteins expressed in vivo.

doi:10.1038/bjc.1998.256

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Article

Temperature sensitivity of human wild-type and mutant p53 proteins expressed in vivo.

British journal of cancer - 1 May 1998

Ponchel F, Milner J

Abstract excerpt

p53 is activated in response to DNA damage and functions in the maintenance of genetic integrity. Loss of p53 function because of mutation of the p53 gene is associated with over half all human cancers. Certain human p53 mutants are conformationally flexible in vitro and are temperature sensitive...

Topics

Apoptosis
Cells, Cultured
Humans
Mutation
Temperature
Transcriptional Activation
Transfection
Tumor Suppressor Protein p53

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