Article
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.
Genes & development - 1 Dec 1993
Bargonetti J, Manfredi J J, Chen X, Marshak D R, Prives C
Abstract excerpt
p53 is a sequence-specific DNA-binding oligomeric protein that can activate transcription from promoters bearing p53-binding sites. Whereas the activation region of p53 has been identified within the amino terminus, the location of the specific DNA-binding domain has not been reported. Thermolysi...
Topics
- Base Sequence
- Binding Sites
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Peptide Fragments
- Recombinant Proteins
- Thermolysin
- Tumor Suppressor Protein p53