Article
Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.
The Journal of biological chemistry - 20 Oct 1995
Chang J, Kim D H, Lee S W, Choi K Y, Sung Y C
Abstract excerpt
Tumor suppressor protein p53 is a potent transcriptional activator and regulates cell growth negatively. To characterize the transcriptional activation domain (TAD) of p53, various point mutants were constructed in the context of Gal4 DNA binding domain and tested for their transactivation abilit...
Topics
- Amino Acid Sequence
- Base Sequence
- Circular Dichroism
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Structure-Activity Relationship
- TATA Box
- TATA-Box Binding Protein
- Transcription Factors
- Transcriptional Activation
- Tumor Suppressor Protein p53