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Article

Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.

The Journal of biological chemistry - 20 Oct 1995

Chang J, Kim D H, Lee S W, Choi K Y, Sung Y C

Abstract excerpt

Tumor suppressor protein p53 is a potent transcriptional activator and regulates cell growth negatively. To characterize the transcriptional activation domain (TAD) of p53, various point mutants were constructed in the context of Gal4 DNA binding domain and tested for their transactivation ability. Our results demonstrated that the positionally conserved hydrophobic residues shared with herpes simplex virus VP16...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7559631
DOI: 10.1074/jbc.270.42.25014

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transactivation ability of p53 transcriptional activation domain is directly related to the binding affinity to TATA-binding protein.PMID 7559631Read ↗

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