Article
Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance.
Nucleic acids research - 1 Nov 2011
Aramayo Ricardo, Sherman Michael B, Brownless Kathryne, Lurz Rudi, Okorokov Andrei L, Orlova Elena V
Abstract excerpt
The p53 tumour suppressor is a transcriptional activator that controls cell fate in response to various stresses. p53 can initiate cell cycle arrest, senescence and/or apoptosis via transactivation of p53 target genes, thus preventing cancer onset. Mutations that impair p53 usually occur in the core domain and negate the p53 sequence-specific DNA binding. Moreover, these mutations exhibit a dominant negative...
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