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Article

Synergistic rescue of temperature-sensitive p53 mutants by hypothermia and arsenic trioxide.

Molecular carcinogenesis - 1 Nov 2024

Lu Junhao, Chen Lihong, Fatima Zainab, Huang Jeffrey, Chen Jiandong

Abstract excerpt

The p53 tumor suppressor is inactivated by mutations in about 50% of tumors. Rescuing the transcriptional function of mutant p53 has potential therapeutic benefits. Approximately 15% of p53 mutants are temperature sensitive (TS) and regain maximal activity at 32°C. Proof of concept study showed that induction of 32°C hypothermia in mice restored TS mutant p53 activity and inhibited tumor growth. However, 32°C is...

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Identifiers

PMID: 39115446
DOI: 10.1002/mc.23804
PMCID: PMC11466696

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