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Transactivation by temperature-dependent p53 mutants in yeast and human cells.

Cell cycle (Georgetown, Tex.) - 1 Jun 2010

Slovackova Jana, Grochova Diana, Navratilova Jarmila, Smarda Jan, Smardova Jana

Abstract excerpt

The p53 protein plays an important role in cancer prevention. In response to stress signals, p53 controls essential cell functions by regulating expression of its target genes. Full or partial loss of the p53 function in cancer cells usually results from mutations of the p53 gene. Some of them are temperature-dependent, allowing reactivation of the p53 function in certain temperature. These mutations can alter...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20505364
DOI: 10.4161/cc.9.11.11808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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