Article
Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells.
International journal of oncology - 1 Sept 2012
Jagosova Jana, Pitrova Lenka, Slovackova Jana, Ravcukova Barbora, Smarda Jan, Smardova Jana
Abstract excerpt
The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. We analyzed the transactivating activity of nine human temperature-dependent (td) p53 mutants in yeast cells....
Topics
- Amifostine
- Genes, p53
- Humans
- Mutation
- Radiation-Protective Agents
- Temperature
- Transcriptional Activation
- Transformation, Genetic
- Tumor Suppressor Protein p53
- Yeasts