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Article

The INK4A/ARF locus and its two gene products.

Current opinion in genetics & development - 1 Feb 1999

Sharpless N E, DePinho R A

Abstract excerpt

The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.

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Share to Amino Acid Sequence
Share to Cyclin-Dependent Kinase Inhibitor p16
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Amino Acid

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 10072356
DOI: 10.1016/s0959-437x(99)80004-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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