Article
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.
Molecular and cellular biology - 1 Dec 2002
Huot Thomas J, Rowe Janice, Harland Mark, Drayton Sarah, Brookes Sharon, Gooptu Chandra, Purkis Patricia, Fried Mike, Bataille Veronique, Hara Eiji, Newton-Bishop Julia, Peters Gordon
Abstract excerpt
The INK4a/ARF tumor suppressor locus is implicated in the senescence-like growth arrest provoked by oncogenic Ras in primary cells. INK4a and ARF are distinct proteins encoded by transcripts in which a shared exon is decoded in alternative reading frames. Here we analyze dermal fibroblasts (designated Q34) from an individual carrying independent missense mutations in each copy of the common exon. Both mutations...
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