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Article

Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms

9 Sept 2022

Abstract excerpt

9p21 locus is one of the most reproducible regions in genome-wide association studies (GWAS). The region harbors CDKN2A/B genes that code for p16INK4a, p15INK4b, and p14ARF proteins, and it also harbors a long gene desert adjacent to these genes. The polymorphisms that are associated with several diseases and cancers are present in these genes and the gene desert region. These proteins are critical cell cycle...

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PMID: 36158211
DOI: 10.3389/fcell.2022.948351

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