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Article

Distinct versus redundant properties among members of the INK4 family of cyclin‐dependent kinase inhibitors

20 Mar 2000

Abstract excerpt

p16(INK4a), p15(INK4b), p18(INK4c) and p19(INK4d) comprise a family of cyclin-dependent kinase inhibitors and tumor suppressors. We report that the INK4 proteins share the ability to arrest cells in G1, and interact with CDK4 or CDK6 with similar avidity. In contrast, only p18 and particularly p19 are phosphorylated in vivo, and each of the human INK4 proteins shows unique expression patterns dependent on cell...

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PMID: 10734227
DOI: 10.1016/s0014-5793(00)01307-7

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