Article
A glycyl radical site in the crystal structure of a class III ribonucleotide reductase.
Science (New York, N.Y.) - 5 Mar 1999
Logan D T, Andersson J, Sjöberg B M, Nordlund P
Abstract excerpt
Ribonucleotide reductases catalyze the reduction of ribonucleotides to deoxyribonucleotides. Three classes have been identified, all using free-radical chemistry but based on different cofactors. Classes I and II have been shown to be evolutionarily related, whereas the origin of anaerobic class III has remained elusive. The structure of a class III enzyme suggests a common origin for the three classes but shows...
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