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Article

Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994

Aslund F, Ehn B, Miranda-Vizuete A, Pueyo C, Holmgren A

Abstract excerpt

Thioredoxin (Trx) and glutaredoxin (Grx1) are hydrogen donors for ribonucleotide reductase, the key enzyme for deoxyribonucleotide biosynthesis. The viability of a double mutant lacking both Trx and Grx1 implies the presence of a third, unknown hydrogen donor. This paper reports the purification and characterization of two proteins with glutaredoxin activity (using hydroxyethyl disulfide as a substrate) from an...

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Identifiers

PMID: 7937896
DOI: 10.1073/pnas.91.21.9813
PMCID: PMC44907

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Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.PMID 7937896Read ↗

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