Article

Metal-independent ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

2018-06-15

Abstract excerpt

Ribonucleotide reductase (RNR) catalyzes the only known de-novo pathway for production of all four deoxyribonucleotides required for DNA synthesis. In aerobic RNRs, a di-nuclear metal site is viewed as an absolute requirement for generating and stabilizing an essential catalytic radical. Here we describe a new group of RNRs found in Mollicutes, including Mycoplasma pathogens, that possesses a metal-independent sta...

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Literature Corpus work: e7ee4a60-5453-5d0d-8104-17d2e7b5bbe2
DOI: 10.1101/348268

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