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Starting a new chapter on class Ia ribonucleotide reductases

19 Oct 2022

Abstract excerpt

Ribonucleotide reductases (RNRs) use radical-based chemistry to convert ribonucleotides into deoxyribonucleotides, an essential step in DNA biosynthesis and repair. There are multiple RNR classes, the best studied of which is the class Ia RNR that is found in Escherichia coli, eukaryotes including humans, and many pathogenic and nonpathogenic prokaryotes. This review covers recent advances in our understanding of...

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PMID: 36272229
DOI: 10.1016/j.sbi.2022.102489

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