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Article

Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Berthold Catrine L, Wang He, Nordlund Stefan, Högbom Martin

Abstract excerpt

ADP-ribosylation is a ubiquitous regulatory posttranslational modification involved in numerous key processes such as DNA repair, transcription, cell differentiation, apoptosis, and the pathogenic mechanism of certain bacterial toxins. Despite the importance of this reversible process, very little is known about the structure and mechanism of the hydrolases that catalyze removal of the ADP-ribose moiety. In the...

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Identifiers

PMID: 19706507
DOI: 10.1073/pnas.0905906106
PMCID: PMC2732831

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